Marie Tannous is a full time assistant professor in the Faculty of Natural and Applied Sciences at Notre Dame University North Campus. She was awarded the Natural Sciences and Engineering Research Council of Canada scholarship to pursue her Ph.D. in Clinical Chemistry at the University of Windsor. Her long term research focuses on the clinical aspects of nitric oxide and related compounds.  The work for her latest publication in the journal of diabetes, Essential role for membrane lipid rafts in interleukin-1 beta-induced nitric oxide release from insulin-secreting cells: potential regulation by caveolin-1, was conducted at Wayne State University where she was involved extensively in research.  She is currently interested in pursuing research in the area of diabetes focusing on the relationship[s] between nitric oxide and the dysfunction of mitochondrial proteins leading to the demise of pancreatic beta cell in type I diabetes. She currently teaches courses related to the areas of Biochemistry, Biology and Nutrition.

Ph.D. in Clinical Chemistry, University of Windsor, Ontario, Canada, 1998

B.Sc. honours Biochemistry, University of Windsor, Ontario, Canada, 1994

B.Sc. General Science, University of Windsor, Ontario, Canada, 1993

Diploma, Medical Laboratory Technology, St. Clair College, Ontario, Canada, 1990

Refereed Journal Articles

Veluthakal, R., Chvyrkova, I., Tannous, M., McDonald, P., Amin, R., Hadden, T., Quon, M., Kowluru, A. (2005) Essential role for membrane lipid rafts in interleukin-1beta-induced nitric oxide release from insulin-secreting cells: potential regulation by caveolin-1. Diabetes; 54(9):2576-2585.

Chen, H., Tannous, M., Veluthakal, R., Amin, R., Kowluru, A. (2003) Novel roles for palmitoylation of Ras in IL-1b-induced nitric oxide release and caspase-3 activation in insulin-secreting b cells. Biochem Pharmacol.; 66(9):1681-1694.

Kowluru, A., Chen, H., Tannous, M. (2003) Novel roles for the Rho subfamily of GTP-binding proteins in succinate-induced insulin secretion from bTC3 cells: further evidence in support of the succinate mechanism of insulin release.  Endocrine Research;29(3):363-376.

Amin, R., Chen, H., Tannous, M., Gibbs, R., Kowluru, A. (2002) Inhibition of glucose- and calcium-induced insulin secretion from bTC3 cells by novel inhibitors of protein isoprenylation. J. Pharmacol. Exp. Ther. 303(1):82-88.

Tannous, M., Veluthakal, R, Amin, R, Kowluru, A. (2002) IL-1b induced nitric oxide release from insulin secreting cells: Further evidence for the involvement of GTP-binding proteins. Diabetes & Metabolism; 28:3S78-3S84.

Veluthakal, R., Khan, I., Tannous, M., Kowluru, A. (2002) Functional inactivation by IL-1b of glyceraldehyde-3-phosphate dehydrogenase in insulin-secreting cells. Apoptosis; 7:241-246.

Kowluru, A., Tannous, M., Chen, H. (2002) Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase. Arch Biochem Biophys. Feb 15; 398(2):160-169.

Tannous, M., Amin, R., Popoff, M., Fiorentini, C., Kowluru. A. (2001) Positive Modulation by Ras of Interleukin-1b-Mediated Nitric Oxide Generation in the Pancreatic b Cell. Biochemical Pharmacology; 62:1459-1468.

Tannous, M., Hutnik, C., Tingey, D., Mutus, B. (2000) S-Nitrosoglutathione Photolysis as a Novel Therapy for Antifibrosis in Filtration Surgery. Investigative Ophthamology & Visual Science; 41:749-755.

Tannous, M., Cheung, R., Vignini, A., Mutus, B. (1999)  Atorvastatin induces eNOS levels in human platelets of hyperlipidemic subjects. Thromb Haemost; 82:1390-4.

Lafreniere, K., Mutus, B., Cameron, S., Tannous, M. (1999). Effects of therapeutic touch on biochemical and mood indicators in women. J Alter Complement Med; Aug 5(4):367-70.

Tannous, M., Rabini, R., Vignini, A., Moretti, N., Fumelli, P., Zielinski, B., Mazzanti, L., Mutus, B. (1999) Evidence for iNOS-dependent peroxynitrite production in Diabetic Platelets. Diabetologia; 42:539-544.

Dimmock, J., Kandepu, M., Hetherington, M., Quail, W., Pugazhenthi, U., Sudom, A., Chamankhah, M., Rose, P., Pass, E., Allen, T., Halleran, S., Szydlowski, J., Mutus, B., Tannous, M., Manavathu, E., Myers, T., De Clercq, E., Balzarini, J.  (1998) Cytotoxic activities of Mannich bases of Chalcones and related compounds. Journal of Medicinal Chemistry; 41(7):1014-1026.

Tannous, M., Labbe, N., Redmond, R., Mutus, B. (1997)  A photo-activated, protein-based, peroxynitrite generating system composed of the nitric oxide derivative of apo-metallothionein (thionein-NO) and glucose oxidase. Journal of photochemistry and Photobiology; 41:249-254.

Published Abstracts

Veluthakal, R., Chyyrkova, I., Tannous, M., McDonald, P., Amin, R., Hadden, T., Quon, M., Kowluru, A. (2004) Novel Roles for membrane lipid rafts in IL-induced NO release from the islet beta cell: potential regulation by caveolin-1. John D. Dingell VA National Research, USA.

Tannous, M., Veluthakal, R., Amin, R., Kowluru, A. (2003) Localization and phosphorylation of caveolin-1 in insulin-secreting HIT-T15 cells: its novel role[s] in IL1b-induced NO release. Annual Meetings of the American Diabetes Association. New Orleans, Louisiana, USA.

Kowluru, A., Chen, H., Tannous, M. (2003) Novel roles for Rho G-proteins in succinate-induced insulin secretion from bTC3 cells. Annual Meetings of the American Diabetes Association. New Orleans, Louisiana, USA.

Tannous, M., Veluthakal, R., Amin, R., Hadden, T., Chen, H., Quon, M., Kowluru, A. (2003) Novel regulatory roles for caveolin-1 in IL-1b-mediated dysfunction and demise of the islet b cell. John D. Dingell VA National Research, USA.

Tannous, M., Veluthakal, R., Amin, R., Kowluru, A. (2002) Further Evidence that G-proteins are involved in IL-induced NO release from pancreatic b cells. Annual Meetings of the American Diabetes Association. San Francisco, USA.

Veluthakal, R., Khan, I., Tannous, M., Kowluru, A. (2002) Functional inactivation by peroxynitrite of glyceraldehyde-3-phosphate dehydrogenase in pancreatic b cells. Annual Meetings of the American Diabetes Association. San Francisco, USA.

Amin, R., Chen, HQ. Tannous, M., Gibbs, R., Kowluru, A. (2002) Inhibition of glucose-and calcium-induced insulin secretion by novel inhibitors of protein isoprenylation. Annual Meetings of the American Diabetes Association. San Francisco, USA.

Amin, R., Tannous, M., Kowluru, A. (2002) Novel regulatory roles for protein farnesylation in IL-1b-induced nitric oxide release from the pancreatic b cells. Annual Meetings of the American Diabetes Association. San Francisco, USA.

Kowluru, A., Tannous, M., Chen, H., Veluthakal, R., Amin, R., (2002) Palmitoylation of Ras is essential for interleukin-1-b-induced NO release in insulin-secreting cells. Submitted for presentation at the European Association for the study of Diabetes in Budapest.

Tannous, M., Veluthakal, R., Amin, R., Kowluru, A. (2002) Additional Evidence for the involvement of G-proteins in IL-1b-induced nitrite release from insulin-secreting cells. John D. Dingell VA National Research, USA.

Amin, R., Tannous, M., Gibbs, R., Kowluru, A. (2002) Farnesylation of Ras is required for IL-1b-induced nitric oxide release in pancreatic b cells. John D. Dingell VA National Research, USA.

Chen, H., Tannous, M., Veluthakal, R., Amin, R., Kowluru, A. (2002) Palmitoylation of Ras is essential for interleukin-1-b-induced NO release in insulin-secreting cells. John D. Dingell VA National Research, USA.

Tannous, M., Amin, R., Popoff, M., Fiorentini, C., Kowluru, A. (2001) Positive role by Ras of Interleukin-1b-Mediated Nitric Oxide Generation in the Pancreatic Cell. The Endocrine Meeting, USA.

Amin, R., Zahn, T., Chen, H., Tannous, M., Gibbs, R., Kowluru, A. (2001) Inhibition of glucose and calcium-induced insulin secretion from bTC3 cells by novel inhibitors of protein prenylation. The Endocrine Meeting, USA.

Tannous, M., Popoff, M., Kowluru, A. (2000) Specific regulation by Ras of cytokine-mediated nitric oxide generation in the pancreatic b cell. 3rd Annual International Motor City Diabetes Symposium, USA.

Tannous, M., Walsh, M., Reddy, M., Lingam, D., Sowers, J. (2000) Wortmannin inhibits b-estardiol and insulin-like growth factor-1 endothelial nitric oxide synthase induction. 18th Scientific Meeting of International Society of Hypertension, S213, P34.11, USA.

Tannous, M., Tang, N., Amin, R., Chen, H., Kowluru, A. (2000) Unique regulation by Rho subfamily of GTP-binding proteins of cytokine-mediated nitric oxide (NO) production in the islet b cell. John D. Dingell VA National Research, USA.

Tannous, M., Labbe, N., Redmond, R., Mutus, B.  (1996) A photo-activated, protein-based, peroxynitrite generating system composed of the nitric oxide derivative of apo-metallothionein (thioenin-NO) and glucose oxidase. Journal of Clinical Chemistry.