Christophe Tratrat received his Magistère Inter-Universitaire de Chimie in 1996 from the Ecole Normale Supérieure / Pierre et Marie Curie University of Paris and his Ph.D. in 1999 from René Descartes University working in the group of Professor Henri-Philippe Husson on the synthesis of pharmacologically active heterocyclic compounds. A patent for the discovery of a specific molecule to be a promising anti-cancer agent was registered out of his thesis. After nearly two years as Research Associate in the laboratory of Professor Anthony G.M. Barrett at Imperial College in London devoted to solid-phase methodology for the generation of diverse libraries of natural-product-like molecules, he joined the group of Professor Yves Troin at Ecole Nationale Supérieure de Chimie of Clermont-Ferrand, where he was involved in efforts toward the asymmetric synthesis of quinolizidine and indolizidine natural products. Since 2004, He has held the position of Assistant Professor of Chemistry at Notre Dame University. His research interests include synthetic methodology, heterocyclic chemistry, asymmetric synthesis, solid-phase synthesis for combinatorial chemistry and medicinal chemistry in drug discovery.

Diplome de Docteur in Chemistry, University René Descartes, Paris V, France, 1999.

Magistère Inter-Universitaire in Chemitry, Ecole Normale Supérieure of Paris and Pierre et Marie Curie University, Paris VI, France, 1996.

D.E.A. in Organic and Bio-organic Chemistry, Pierre et Marie Curie University, Paris VI, France, 1994.

Maîtrise in Organic and Bio-organic Chemistry , Ecole Normale Supérieure of Paris, France, 1993.

Articles or Chapters in Books

Rougnon-Glasson, S., Tratrat, C., Canet, J.-L., Chalard, P., and Troin, Y. (2004) A b,b’-Ketoamino ester as valuable tool for the asymmetric construction of substituted homopipecolic esters. Application to a synthesis of (+)-Calvine, Tetrahedron Asymmetry,Vol. 60, No. 7, p. 1562.

Tratrat, C., Giorgi-Renailt, S., and Husson, H.-P. (2002) A Multicomponent Reaction for the One-Pot Synthesis of 4-aza-2,3-dehydropodophyllotoxin and derivatives, Organic Letters, No. 19, p. 3187.

MeneyrolL, J., Helissey, P., Tratrat, C., Giorgi-Renailt, and S., Husson, H.-P. (2001) Palladium-Catalyzed N-arylation of Tetrahydroquinoline and Tetrahydroisoquinoline with Arylhalides, Synthetic Communications, No. 31, p. 987.

Husson, H.-P., Giorgi-Renault, S., Tratrat, C., Atassi, G., Pierre, A., Renard, P., and Pfeiffer, B. (2000) New tricyclic quinoline derivatives useful as anticancer agents, Patent: EP1103554-A, US 6548515.

Tratrat, C., Giorgi-Renailt, S., and Husson, H.-P. (2000) Oxidative cleavage of indole-d-lactones with m-chloroperbenzoic acid : First Synthesis of Spiroindoline-2-one-g-lactones.  J. Org. Chem., No. 65, p. 6773.

Tratrat, C., Giorgi-Renailt, S., and Husson, H.-P. (1998) A convenient route to quinolone-fused imides and lactams : synthesis of pyrrolo[3,4-b]quinoline-3,9-diones and 1,3,9-triones by oxydation of indole derivatives. Synlett, p. 1071.

Conference Proceedings

Rougnon-Glasson, S., Tratrat, C., Canet, J.-L., Chalard, P., and Troin, Y. (2004) A b,b’-Ketoamino ester as valuable tool for the asymmetric construction of Homopipecolic esters.17th French-Japanese Symposium on Medicinal and Fine Chemistry. Tohoku University, Japan, May.


Tratrat, C., Giorgi-Renault, S., and Husson, H.-P. (2001) Les 4-azapodophyllotoxines : nouvelles molécules à forte activité antitumorale, inhibitrices de la polymérisation de la tubuline. XXXVII Rencontres Internationales de Chimie Thérapeutique. Tours, July.


Tratrat, C., Giorgi-Renault, S., and Husson, H.-P. (1999) Synthèse et étude de la réactivité de pyrroloquinoléines : pyrrolo[3,4-b]quinoléine-1,3,9-triones, 1,9-diones ou 3,9-diones. XXXV Rencontres Internationales de Chimie Thérapeutique, Rouen, July.


Tratrat, C., Giorgi-Renault, S., and Husson, H.-P. (1999) A convenient route to quinolone-fused imides and lactams: synthesis of pyrrolo[3,4-b]quinoline-3,9-diones and 1,3,9-triones by oxydation of indole derivatives.Ninth fechem Conference on Heterocycles in Bio-Organic Chemistry, Aussois, May.